Alpha adrenergic receptor blockade increases capillarization and fractional O2extraction and lowers blood flow in contracting human skeletal muscle
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چکیده
منابع مشابه
Combined NO and PG inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscle.
Sympathetic alpha-adrenergic vasoconstrictor responses are blunted in the vascular beds of contracting muscle (functional sympatholysis). We tested the hypothesis that combined inhibition of nitric oxide (NO) and prostaglandins (PGs) restores sympathetic vasoconstriction in contracting human muscle. We measured forearm blood flow via Doppler ultrasound and calculated the reduction in forearm va...
متن کاملAlpha-adrenergic receptor-mediated restraint of skeletal muscle blood flow during prolonged exercise.
Sympathetic nervous system restraint of skeletal muscle blood flow during dynamic exercise has been well documented. However, whether sympathetic restraint of muscle blood flow persists and is constant throughout prolonged exercise has not been established. We hypothesized that both alpha1- and alpha2-adrenergic receptors would restrain skeletal muscle blood flow throughout prolonged constant-l...
متن کاملInvited Review HIGHLIGHTED TOPIC Skeletal and Cardiac Muscle Blood Flow Vasodilatory mechanisms in contracting skeletal muscle
Clifford, Philip S., and Ylva Hellsten. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97: 393–403, 2004; 10.1152/japplphysiol.00179. 2004.—Skeletal muscle blood flow is closely coupled to metabolic demand, and its regulation is believed to be mainly the result of the interplay of neural vasoconstrictor activity and locally derived vasoactive substances. Muscle blood flo...
متن کاملCilostazol increases tissue blood flow in contracting rabbit gastrocnemius muscle.
BACKGROUND The mechanisms underlying the ability of cilostazol to improve walking distance in patients with intermittent claudication (IC) are not fully understood, but may be related to its phosphodiesterase type 3 (PDE3) and adenosine uptake inhibition. In the present study the effect of cilostazol on blood flow and interstitial adenosine concentration was compared with that of the PDE3 inhib...
متن کاملExercise attenuates alpha-adrenergic-receptor responsiveness in skeletal muscle vasculature.
Attenuation of sympathetic vasoconstriction (sympatholysis) in working muscles during dynamic exercise is controversial. A potential mechanism is a reduction in alpha-adrenergic-receptor responsiveness. The purpose of this study was to examine alpha(1)- and alpha(2)-adrenergic-receptor-mediated vasoconstriction in resting and exercising skeletal muscle using intra-arterial infusions of selectiv...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2017
ISSN: 1748-1708
DOI: 10.1111/apha.12857